Background and purpose: Escherichia coli Nissle 1917 is a probiotic strain used in the treatment of intestinal immune diseases, including ulcerative colitis. The aim of the present study was to test if this probiotic bacterium can also show systemic immunomodulatory properties after oral administration. One such example is the probiotic bacterium Escherichia coli Nissle 1917 (E. coli Nissle, or EcN), a strain that was first isolated in WWI from the stool of a soldier who did not develop Our results suggest that if both the microbiota and adaptive immunity are defective, translocation across the intestinal epithelium and dissemination of the probiotic E. coli strain Nissle 1917 may occur and have potentially severe adverse effects.
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The probiotic Escherichia coli strain Nissle 1917 is in addition to some Lactobacilli sp. one of the best-studied probiotic strains. This particular E. coli strain was isolated in 1917 based on its potential to protect from presumably infectious gastroenteritis. Initial therapeutic success was noted …
An update on the role of EcN 1917 in maintenance of remission in UC patients, including data about efficacy and safety is proposed, and the only probiotic recommended in ECCO guidelines as effective alternative to mesalazine is proposed. Ulcerative colitis (UC) is a chronic inflammatory disease, whose etiology is still unclear. Its pathogenesis involves an interaction between genetic factors
Conclusions: The probiotic drug E coli Nissle 1917 shows efficacy and safety in maintaining remission equivalent to the gold standard mesalazine in patients with ulcerative colitis. The effectiveness of probiotic treatment further underlines the pathogenetic significance of the enteric flora. Aims To assess protective efficacy of genetically modified Escherichia coli Nissle 1917 (EcN) on metabolic effects induced by chronic consumption of dietary fructose. Materials and Methods EcN was genetically modified with fructose dehydrogenase (fdh) gene for conversion of fructose to 5-keto-D-fructose and mannitol-2-dehydrogenase (mtlK) gene for conversion to mannitol, a prebiotic. Charles We genetically engineer Escherichia coli Nissle 1917 (EcN) to create fibrous matrices that promote gut epithelial integrity in situ. These matrices consist of curli nanofibers displaying This study investigated the ability of probiotic Escherichia coli Nissle 1917 (EcN) to outcompete the biofilm formation of pathogens including enterohemorrhagic E. coli (EHEC), Pseudomonas aeruginosa, Staphylococcus aureus, and S. epidermidis. Furthermore, the ability of S. boulardii to colonise the antibiotic-treated mice were 10- to 100-fold lower than some of the more common bacterial probiotics 53,54, such as E. coli Nissle 1917 Escherichia coli is one of the earliest probiotic bacterial strains to be developed for human therapeutic use (Nissle A, 1916). Among probiotic E. coli strains, E. coli Nissle (EcN) 1917 has been the topic of numerous studies in humans since its discovery in the early 1900s, and is marketed in Germany and other countries under the brand name
Background: Pathogenic adherent-invasive Escherichia coli have been isolated from ileal lesions of Crohn's disease. Aim: : To investigate the non-pathogenic E. coli strain Nissle 1917 (Mutaflor) as possible maintenance therapy in inflammatory bowel disease by testing its ability to prevent adherent-invasive E. coli strains from adhering to and invading human intestinal epithelial cells in vitro.
To assess the impact of the intestinal microbiota on protection of mice with severely compromised adaptive immunity from bacterial translocation, we challenged GF- or SPF-raised Rag1 −/− mice orally with E. coli strain Nissle 1917, a probiotic E. coli strain used to treat IBD and other intestinal diseases , or with E. coli mpk, a commensal
Probiotics are viable non-pathogenic microorganisms that confer health benefits to the host by improving the microbial balance of the indigenous microflora. 9 Apart from anecdotal experience, two controlled studies with the probiotic bacterial strain Escherichia coli Nissle 1917 (EcN) in UC already exist. 10, 11 These trials showed no
Probiotic Escherichia coli Nissle 1917 inhibits bacterial persisters that survive fluoroquinolone treatment Abstract. Bacterial persisters are rare phenotypic variants in clonal bacterial cultures that can endure antimicrobial INTRODUCTION. Bacteria can deploy diverse strategies to overcome the
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The K5 capsule of Escherichia coli strain Nissle 1917 is important in mediating interactions with intestinal epithelial cells and chemokine induction. Infect. Immun. 77 , 2995–3003 (2009).
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Blocks Intestinal Inflammation. April 3, 2023. Researchers at Massachusetts General Hospital (MGH) have engineered a strain of the probiotic Escherichia coli ( E. coli ), Nissle 1917, to secrete
A century ago, Alfred Nissle discovered that intentional intake of particular strains of Escherichia coli could treat patients suffering from infectious diseases. Since then, one of these strains became the most frequently used probiotic E. coli in research and was applied to a variety of human conditions. Here, properties of that E. coli
Huff, G. R. et al. Oral treatment with the probiotic Escherichia coli Nissle 1917 improves body weight and modulates the stress response of poultry in respiratory challenges with avian pathogenic .